1. Key West Reef Mooring Buoy Program: Protected Key West's coral reefs from the enormous local fleet of charter boats by installing and maintaining 116 mooring buoys at six Key West-area coral reefs for a period of 10 years. This was the largest privately-maintained system in the world and is now part of  the Florida Keys National Marine Sanctuary Reef Mooring Buoy Action Plan. Innovations included the U-bolt for larger vessels and the self-cleaning buoy line. 

2. Clean Water Campaign: Spearheaded a campaign to improve water quality for Florida's coral reefs. Reef Relief was a major supporter of the effort to create the Florida Keys National Marine Sanctuary including the first Water Quality Protection Program of any sanctuary. Led the effort to phase out ocean outfalls with advanced treatment and reuse for all of South Florida following the lead of Key West, which phased out its ocean outfall many years ago. Initiated the effort for the Florida Keys to be designated a No Discharge Zone for boater sewage.  Reef Relief is a watchdog for other threats to coral reefs such as offshore oil and beach renourishment and supported efforts to designate Elkhorn and Staghorn corals to the U.S. Endangered Species list to gain added protection for them.

3. Jamaica Coral Reef Protection Program: In November of 1991, Reef Relief worked with the Negril Coral Reef Preservation Society (NCRPS) to install 35 reef mooring buoys at the reefs of Negril, Jamaica. In subsequent years, Reef Relief returned to train local preservationists to patrol their reefs with the Reef Ranger Program, maintain the buoys, install a swimmer's lane, launch a Junior Ranger school program, and create the Negril Marine Park, managed by NCRPS.

4. Coral Reef Conservation Program: Reef Relief maintains the Environmental Center in Key West and educates Florida residents and visitors and others around the world on the benefits and methods of protecting the reef ecosystem including the Discover Coral Reefs School Program, summer Coral Camp, Reef Ranger Program and more.  Its website offers tools for educators and students and its online community is advised of coral reef news and issues and opportunities to get involved.

5. Coral Photo Monitoring Survey: From 1987--2007, Reef Relief's founder Craig Quirolo monitored the reef health of many coral reefs near Key West on a slide and video format that led to the discovery and study of several new diseases in cooperation with the world's leading coral reef scientists. The survey has been expanded to coral reefs in Jamaica, Puerto Rico, Cuba, Mexico, St. Kitts, St. Marteen, and the Bahamas and is now available via an Online Archive at www.reefrelief.org. Quirolo has also produced many short videos on reef health now posted at Youtube.com. 

6. Guanaja, Bay Islands, Honduras Project: Reef Relief in cooperation with the Guanaja Tourism association, installed 36 reef mooring buoys to protect the fragile coral reefs surrounding the island of Guanaja, a popular dive destination off the coast of Honduras.

7. Coral Nursery Project: In 1998 and 2000, working in conjunction with Harold Hudson of the Florida Keys National Marine Sanctuary, Reef Relief established a Coral Nursery at Western Sambo Reef in the Lower Keys and at Nonmame Cay in the Abaco, Bahamas,  that salvaged storm damaged corals, secured them to the ocean bottom and elevated them so that they may survive. These elkhorn corals are now on the endangered species list so our efforts helped save them.

8. The Bahamas Project: Reef Relief is creating a coral reef conservation ethic at GreenTurtle Cay in the Abaco, Bahamas, that includes operation of the Captain Roland Roberts House Environmental Center, a system of 18 reef mooring buoys, a recycling program, marine debris clean-ups, a green bag project to avoid plastics, and a native bush medicine garden.

9. The Cuba Project:  Beginning in 1998, Reef Relief conducted three surveys of Cuban coral reefs in cooperation with Cuban coral reef scientists and has supported coral reef educational programs in Cuba in cooperation with Aculina, a nonprofit organization founded by Angelita Corvea.